ClC Channels: Reading Eukaryotic Function through Prokaryotic Spectacles
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Bacterial ion channels and their eukaryotic homologues.
Due to the relative ease of obtaining their crystal structures, bacterial ion channels provide a unique opportunity to analyse structure and function of their eukaryotic homologues. This review describes prokaryotic channels whose structures have been determined. These channels are KcsA, a bacterial homologue of eukaryotic potassium channels, MscL, a bacterial mechanosensitive ion channel and C...
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CLC-ec1 is an E. coli homologue of the CLC family of Cl- channels, which are widespread throughout eukaryotic organisms. The structure of this membrane protein is known, and its physiological role has been described, but our knowledge of its functional characteristics is severely limited by the absence of electrophysiological recordings. High-density reconstitution and incorporation of crystall...
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ClC proteins are a family of chloride channels and transporters that are found in a wide variety of prokaryotic and eukaryotic cell types. The mammalian voltage-gated chloride channel ClC-1 is important for controlling the electrical excitability of skeletal muscle. Reduced excitability of muscle cells during metabolic stress can protect cells from metabolic exhaustion and is thought to be a ma...
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It's a truism that structures are helpful for mechanistic understanding of protein function, and nowhere is this dictum better illustrated than with ClC-type Cl Ϫ channels , a large molecular family found in virtually every type of cell in every biological niche. These channels, first observed over 20 yr ago (White and Miller, 1979; Miller, 1982), are now known from a barrage of knockout studie...
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تاریخ انتشار 2003